Jannik Sinner and Carlos Alcaraz qualified for the quarterfinals in Cincinnati, while Terence Atmane knocked out top seed Taylor Fritz.

Jannik Sinner, the defending champion, won his match against Adrian Mannarino to advance to the quarterfinals, where he will meet Felix Auger-Aliassime. Carlos Alcaraz got a clear victory over Luca Nardi and will face Andrei Rublev for a place in the semi-finals. Terence Atmane pulled off an upset by eliminating Taylor Fritz, and Holger Rune advanced after Frances Tiafoe's withdrawal.