A revolutionary discovery in biomedicine has been made by researchers at the Department of Biomedicine and the University Hospital Basel, who have created a human bone marrow model capable of producing blood cells in the laboratory. This miniature "blood factory," made exclusively from human cells, faithfully reproduces the structure and function of bone marrow, providing a valuable platform for studying blood cancers and testing drugs, thus reducing the need for animal experiments.
The model was built on an artificial scaffold made of hydroxyapatite, which allowed for the introduction of reprogrammed human cells. These cells were guided to differentiate into specific cell types of the marrow, resulting in a structure that mimics the human endosteal niche. This achievement not only enhances the understanding of the hematopoiesis process but also opens up the possibility of developing personalized therapies for patients with hematological cancers.
The researchers emphasize the importance of this model in complementing data obtained from studies on mice, considering the differences between human and animal mechanisms. Although the model requires improvements for clinical use, it represents a significant step towards the development of functional human models that can accelerate research in biomedicine and personalized medicine.
The model was built on an artificial scaffold made of hydroxyapatite, which allowed for the introduction of reprogrammed human cells. These cells were guided to differentiate into specific cell types of the marrow, resulting in a structure that mimics the human endosteal niche. This achievement not only enhances the understanding of the hematopoiesis process but also opens up the possibility of developing personalized therapies for patients with hematological cancers.
The researchers emphasize the importance of this model in complementing data obtained from studies on mice, considering the differences between human and animal mechanisms. Although the model requires improvements for clinical use, it represents a significant step towards the development of functional human models that can accelerate research in biomedicine and personalized medicine.
Sources
Descoperire fără precedent în biomedicină. Cercetătorii au creat o măduvă osoasă umană care produce sânge
Premieră la nivel mondial: Cercetătorii din Basel au creat în laborator măduvă osoasă umană funcțională, care a reușit să producă celule sanguine în mod susținut
Premieră la nivel mondial: Cercetătorii din Basel au creat în laborator măduvă osoasă umană funcțională, care a reușit să producă celule sanguine în mod susținut
Latest News
13:21
Meteoplus: The drought in Central Europe keeps the Danube at critical levels, despite the abundant rainfall in Romania
12:57
Latvia has closed its border with Belarus citing technical reasons amid an increase in illegal crossings.
12:32
New online fraud campaign: criminals present themselves as the Romanian Police and send SMS messages with alleged traffic fines and short payment deadlines.
11:30
South Korea records a historic high of 42.5°C in Yangsan, the highest temperature since 1904
11:11
The resources of the U.S. Navy are insufficient for the defense of Israel, warns the highest American military official in Europe.
See more news