Jared Isaacman, pilot and entrepreneur, was nominated by Trump for the position of NASA administrator, replacing Sean Duffy.

Jared Isaacman was nominated by Donald Trump for the position of NASA administrator after being removed from the race to lead the agency at the beginning of 2025, following a dispute between Trump and Elon Musk. Sean Duffy, the head of the U.S. Department of Transportation, was appointed interim. Isaacman's nomination, a billionaire and successful astronaut, must be confirmed by the Senate, where the Republican Party holds a majority. Isaacman, known for commanding the first civil space crew in 2021, navigated the confirmation process, balancing the Trump administration's goals of exploring Mars with NASA's plans to return to the Moon. Trump emphasized Isaacman's passion and experience as essential for leading NASA into a new era of space exploration. Isaacman is the founder of Shift4 Payments.